| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-ATP-dependent RNA helicase DDX50 (140-220 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DDX50 |
| Gene ID: | 79009 |
| Uniprot ID: | DDX50_HUMAN |
| Immunogen Region: | 140-220 aa |
| Specificity: | DDX50 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 140-220 |
| Function | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production. Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses. For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection. Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta. |
| Protein Name | Atp-Dependent Rna Helicase Ddx50Dead Box Protein 50Gu-BetaNucleolar Protein Gu2 |
| Database Links | |
| Cellular Localisation | NucleusNucleolusCytoplasmAccumulates In The Cytoplasm To Activate Signaling Upstream Of Irf3 During Viral Infection |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Ddx50 antibodyAnti-Dead Box Protein 50 antibodyAnti-Gu-Beta antibodyAnti-Nucleolar Protein Gu2 antibodyAnti-DDX50 antibody |
Information sourced from Uniprot.org
