| Tissue Specificity | Highest expression in skeletal muscle, liver, heart, placenta, and kidney. |
| Function | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production. Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses. For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection. Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta. |
| Protein Name | Atp-Dependent Rna Helicase Ddx50Dead Box Protein 50Gu-BetaNucleolar Protein Gu2 |
| Database Links | |
| Cellular Localisation | NucleusNucleolusCytoplasmAccumulates In The Cytoplasm To Activate Signaling Upstream Of Irf3 During Viral Infection |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Ddx50 antibodyAnti-Dead Box Protein 50 antibodyAnti-Gu-Beta antibodyAnti-Nucleolar Protein Gu2 antibodyAnti-DDX50 antibody |
Information sourced from Uniprot.org
