| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DDX46 |
| Gene ID: | 9879 |
| Uniprot ID: | DDX46_HUMAN |
| Immunogen Region: | 682-1031 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 682-1031 of human DDX46 (NP_055644.2). |
| Immunogen Sequence: | GLDVKHLILVVNYSCPNHYE DYVHRAGRTGRAGNKGYAYT FITEDQARYAGDIIKALELS GTAVPPDLEKLWSDFKDQQK AEGKIIKKSSGFSGKGFKFD ETEQALANERKKLQKAALGL QDSDDEDAAVDIDEQIESMF NSKKRVKDMAAPGTSSVPAP TAGNAEKLEIAKRLALRINA QKNLGIESQDVMQQATNAIL RGGTILAPTVSAKTIAEQLA EKINAKLNYVPLEKQEEER |
| Function | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx46Dead Box Protein 46Prp5 Homolog |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleNucleusCajal BodyPresent In Cajal Bodies (Cbs) And Nuclear Speckles |
| Alternative Antibody Names | Anti-Probable Atp-Dependent Rna Helicase Ddx46 antibodyAnti-Dead Box Protein 46 antibodyAnti-Prp5 Homolog antibodyAnti-DDX46 antibodyAnti-KIAA0801 antibody |
Information sourced from Uniprot.org