Anti-DDX23 antibody (STJA0008967)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DDX23
General Information
| Short Description | Rabbit polyclonal anti-Probable ATP-dependent RNA helicase DDX23 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DDX23 |
| Gene ID | 9416 |
| Uniprot ID | DDX23_HUMAN |
| Immunogen | Synthesized peptide derived from human DDX23 |
| Specificity | This antibody detects endogenous levels of DDX23 at Human |
Additional Info
| Function | Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription.R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx23100 Kda U5 Snrnp-Specific ProteinDead Box Protein 23Prp28 HomologU5-100kd |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | NucleusChromosomeDuring TranscriptionAccumulates At Chromatin Loci Where Unscheduled R-Loops Form And Colocalizes With Paused 'Ser-5'-Phosphorylated Polr2a/Rna Polymerase Ii And Kinase Srpk2 |
| Alternative Antibody Names | Anti-Probable Atp-Dependent Rna Helicase Ddx23 antibodyAnti-100 Kda U5 Snrnp-Specific Protein antibodyAnti-Dead Box Protein 23 antibodyAnti-Prp28 Homolog antibodyAnti-U5-100kd antibodyAnti-DDX23 antibody |
Information sourced from Uniprot.org