| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DDX20 (25-280) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:10-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DDX20 |
| Gene ID: |
11218 |
| Uniprot ID: |
DDX20_HUMAN |
| Immunogen Region: |
25-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human DDX20 (NP_009135.4). |
| Immunogen Sequence: |
VQVPAPEPTPGPVRILRTAQ DLSSPRTRTGDVLLAEPADF ESLLLSRPVLEGLRAAGFER PSPVQLKAIPLGRCGLDLIV QAKSGTGKTCVFSTIALDSL VLENLSTQILILAPTREIAV QIHSVITAIGIKMEGLECHV FIGGTPLSQDKTRLKKCHIA VGSPGRIKQLIELDYLNPGS IRLFILDEADKLLEEGSFQE QINWIYSSLPASKQMLAVSA TYPEFLANALTKYMRDPTF |
| Tissue Specificity | Ubiquitous. |
| Function | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx20Component Of Gems 3Dead Box Protein 20Dead Box Protein Dp 103Gemin-3 |
| Database Links | Reactome: R-HSA-191859Reactome: R-HSA-9754678 |
| Cellular Localisation | CytoplasmNucleusGemLocalized In Subnuclear Structures Next To Coiled BodiesCalled Gemini Of Cajal Bodies (Gems) |
| Alternative Antibody Names | Anti-Probable Atp-Dependent Rna Helicase Ddx20 antibodyAnti-Component Of Gems 3 antibodyAnti-Dead Box Protein 20 antibodyAnti-Dead Box Protein Dp 103 antibodyAnti-Gemin-3 antibodyAnti-DDX20 antibodyAnti-DP103 antibodyAnti-GEMIN3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
