![Anti-DCX nanobody [SAA1176] (STJN000046)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200659/412841/STJN000046-SDS-PAGE-1__47805.1749232391.jpg?c=1 "Anti-DCX nanobody [SAA1176] (STJN000046)")
![Anti-DCX nanobody [SAA1176] (STJN000046)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200659/412841/STJN000046-SDS-PAGE-1__47805.1749232391.jpg?c=1 "Anti-DCX nanobody [SAA1176] (STJN000046)")
Anti-DCX nanobody [SAA1176] (STJN000046)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Neuronal Migration Protein Doublecortin is suitable for use in ELISA and SPR research applications. |
| Applications | ELISA/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1176 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | DCX |
| Gene ID | 1641 |
| Uniprot ID | DCX_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules. Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21. Ubiquitinated by MDM2, leading to its degradation by the proteasome. Ubiquitinated by MDM2 and subsequent degradation leads to reduce the dendritic spine density of olfactory bulb granule cells. |
| Function | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. |
| Protein Name | Neuronal Migration Protein DoublecortinDoublinLissencephalin-XLis-X |
| Database Links | Reactome: R-HSA-447043 |
| Cellular Localisation | CytoplasmCell ProjectionNeuron ProjectionLocalizes At Neurite Tips |
| Alternative Nanobody Names | Anti-Neuronal Migration Protein Doublecortin nanobodyAnti-Doublin nanobodyAnti-Lissencephalin-X nanobodyAnti-Lis-X nanobodyAnti-DCX nanobodyAnti-DBCN nanobodyAnti-LISX nanobody |
Information sourced from Uniprot.org