| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-DCN1-like protein 5 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DCUN1D5 |
| Gene ID: | 84259 |
| Uniprot ID: | DCNL5_HUMAN |
| Specificity: | This antibody detects endogenous levels of DCUN1D5 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human DCUN1D5 |
| Post Translational Modifications | Phosphorylation at Ser-41 is independent of cullin's interaction. Phosphorylated in response to both TICAM1 and MYD88 dependent Toll-like receptor (TLR) pathway activation. Phosphorylated in response to IL1B stimulation. |
| Function | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth. |
| Protein Name | Dcn1-Like Protein 5 Dcnl5 Dcun1 Domain-Containing Protein 5 Defective In Cullin Neddylation Protein 1-Like Protein 5 Squamous Cell Carcinoma-Related Oncogene 5 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | Nucleus Cytoplasm Cytoskeleton Spindle Subcellular Localization Is Independent Of The Interaction With Cullins |
| Alternative Antibody Names | Anti-Dcn1-Like Protein 5 antibody Anti-Dcnl5 antibody Anti-Dcun1 Domain-Containing Protein 5 antibody Anti-Defective In Cullin Neddylation Protein 1-Like Protein 5 antibody Anti-Squamous Cell Carcinoma-Related Oncogene 5 antibody Anti-DCUN1D5 antibody Anti-SCCRO5 antibody |
Information sourced from Uniprot.org