Anti-DCTD antibody (1-178) (STJ28162)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DCTD (1-178) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DCTD |
| Gene ID | 1635 |
| Uniprot ID | DCTD_HUMAN |
| Immunogen Region | 1-178 |
| Immunogen Sequence | MSEVSCKKRDDYLEWPEYFM AVAFLSAQRSKDPNSQVGAC IVNSENKIVGIGYNGMPNGC SDDVLPWRRTAENKLDTKYP YVCHAELNAIMNKNSTDVKG CSMYVALFPCNECAKLIIQA GIKEVIFMSDKYHDSDEATA ARLLFNMAGVTFRKFIPKCS KIVIDFDSINSRPSQKLQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human DCTD (NP_001912.2). |
Additional Info
| Function | Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP). |
| Protein Name | Deoxycytidylate DeaminaseDcmp Deaminase |
| Database Links | Reactome: R-HSA-499943 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Deoxycytidylate Deaminase antibodyAnti-Dcmp Deaminase antibodyAnti-DCTD antibody |
Information sourced from Uniprot.org