Tissue Specificity | Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. |
Function | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development. |
Protein Name | Mrna-Decapping Enzyme 1aSmad4-Interacting Transcriptional Co-ActivatorTranscription Factor Smif |
Database Links | Reactome: R-HSA-430039Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-975957 |
Cellular Localisation | CytoplasmP-BodyNucleusCo-Localizes With Nanos3 In The Processing BodiesPredominantly CytoplasmicIn Processing Bodies (Pb)NuclearAfter Tgfb1 TreatmentTranslocation To The Nucleus Depends On Interaction With Smad4 |
Alternative Antibody Names | Anti-Mrna-Decapping Enzyme 1a antibodyAnti-Smad4-Interacting Transcriptional Co-Activator antibodyAnti-Transcription Factor Smif antibodyAnti-DCP1A antibodyAnti-SMIF antibody |
Information sourced from Uniprot.org