| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:2000-1:4000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | DCK |
| Gene ID: | 1633 |
| Uniprot ID: | DCK_HUMAN |
| Immunogen Region: | 1-260 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DCK (NP_000779.1). |
| Immunogen Sequence: | MATPPKRSCPSFSASSEGTR IKKISIEGNIAAGKSTFVNI LKQLCEDWEVVPEPVARWCN VQSTQDEFEELTMSQKNGGN VLQMMYEKPERWSFTFQTYA CLSRIRAQLASLNGKLKDAE KPVLFFERSVYSDRYIFASN LYESECMNETEWTIYQDWHD WMNNQFGQSLELDGIIYLQA TPETCLHRIYLRGRNEEQGI PLEYLEKLHYKHESWLLHRT LKTNFDYLQEVPILTLDVN |
| Post Translational Modifications | Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1. |
| Function | Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine. Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. |
| Protein Name | Deoxycytidine Kinase Dck Deoxyadenosine Kinase Deoxyguanosine Kinase |
| Database Links | Reactome: R-HSA-73614 Reactome: R-HSA-74217 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Deoxycytidine Kinase antibody Anti-Dck antibody Anti-Deoxyadenosine Kinase antibody Anti-Deoxyguanosine Kinase antibody Anti-DCK antibody |
Information sourced from Uniprot.org