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Anti-DCC antibody (1330-1380) (STJ500738)

Western blot with Anti-DCC Antibody (STJ500738). 1) peptide, 2) SKNMC and 3) RA treated SHSY5Y cells at 1:500 dilution in buffer.

Anti-DCC antibody (1330-1380) (STJ500738)

SKU:

STJ500738-100

£441.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	ELISA/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DCC (1330-1380) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-.70 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	DCC
Gene ID:	1630
Uniprot ID:	DCC_HUMAN
Immunogen Region:	1330-1380
Immunogen:	Synthetic peptide taken within amino acid region 1330-1380 on rat DCC protein.

Tissue Specificity	Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
Post Translational Modifications	Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Function	Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Protein Name	Netrin Receptor Dcc Colorectal Cancer Suppressor Immunoglobulin Superfamily Dcc Subclass Member 1 Tumor Suppressor Protein Dcc
Database Links	Reactome: R-HSA-373752 Reactome: R-HSA-376172 Reactome: R-HSA-418885 Reactome: R-HSA-418886 Reactome: R-HSA-418889 Reactome: R-HSA-418890 Reactome: R-HSA-428542
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Netrin Receptor Dcc antibody Anti-Colorectal Cancer Suppressor antibody Anti-Immunoglobulin Superfamily Dcc Subclass Member 1 antibody Anti-Tumor Suppressor Protein Dcc antibody Anti-DCC antibody Anti-IGDCC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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