Anti-DCC antibody (1330-1380) {FITC} (STJ500740)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 1330-1380 on rat DCC protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-DCC (1330-1380) is suitable for use in ELISA and Western Blot research applications. |
| Applications | ELISA/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.50 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | DCC |
| Gene ID | 1630 |
| Uniprot ID | DCC_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 1330-1380 on rat DCC protein. |
| Immunogen Region | 1330-1380 |
Additional Info
| Tissue Specificity | Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. |
| Function | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. |
| Protein Name | Netrin Receptor DccColorectal Cancer SuppressorImmunoglobulin Superfamily Dcc Subclass Member 1Tumor Suppressor Protein Dcc |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-376172Reactome: R-HSA-418885Reactome: R-HSA-418886Reactome: R-HSA-418889Reactome: R-HSA-418890Reactome: R-HSA-428542 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Netrin Receptor Dcc antibodyAnti-Colorectal Cancer Suppressor antibodyAnti-Immunoglobulin Superfamily Dcc Subclass Member 1 antibodyAnti-Tumor Suppressor Protein Dcc antibodyAnti-DCC antibodyAnti-IGDCC1 antibody |
Information sourced from Uniprot.org