| Tissue Specificity | Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis. |
| Function | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation. Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy. Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation. Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation. |
| Protein Name | Ddb1- And Cul4-Associated Factor 12Centrosome-Related Protein Tcc52Testis Cancer Centrosome-Related ProteinWd Repeat-Containing Protein 40a |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleus |
| Alternative Antibody Names | Anti-Ddb1- And Cul4-Associated Factor 12 antibodyAnti-Centrosome-Related Protein Tcc52 antibodyAnti-Testis Cancer Centrosome-Related Protein antibodyAnti-Wd Repeat-Containing Protein 40a antibodyAnti-DCAF12 antibodyAnti-KIAA1892 antibodyAnti-TCC52 antibodyAnti-WDR40A antibody |
Information sourced from Uniprot.org
