| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DBP |
| Gene ID: | 1628 |
| Uniprot ID: | DBP_HUMAN |
| Immunogen Region: | 1-325 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human DBP (NP_001343.2). |
| Immunogen Sequence: | MARPVSDRTPAPLLLGGPAG TPPGGGALLGLRSLLQGTSK PKEPASCLLKEKERKAALPA ATTPGPGLETAGPADAPAGA VVGGGSPRGRPGPVPAPGLL APLLWERTLPFGDVEYVDLD AFLLEHGLPPSPPPPGGPSP EPSPARTPAPSPGPGSCGSA SPRSSPGHAPARAALGTASG HRAGLTSRDTPSPVDPDTVE VLMTFEPDPADLALSSIPGH ETFDPRRHRFSEEELKPQP |
| Tissue Specificity | Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity. |
| Function | This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. |
| Protein Name | D Site-Binding Protein Albumin D Box-Binding Protein Albumin D-Element-Binding Protein Tax-Responsive Enhancer Element-Binding Protein 302 Taxreb302 |
| Database Links | Reactome: R-HSA-1368108 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-D Site-Binding Protein antibody Anti-Albumin D Box-Binding Protein antibody Anti-Albumin D-Element-Binding Protein antibody Anti-Tax-Responsive Enhancer Element-Binding Protein 302 antibody Anti-Taxreb302 antibody Anti-DBP antibody |
Information sourced from Uniprot.org