Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Monoclonal |
Clone ID : | S5061RM |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DBI |
Gene ID: | 1622 |
Uniprot ID: | ACBP_HUMAN |
Immunogen Region: | 1-104 aa |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-104 of human DBI. (NP_001171513.1). |
Immunogen Sequence: | MWGDLWLLPPASANPGTGTE AEFEKAAEEVRHLKTKPSDE EMLFIYGHYKQATVGDINTE RPGMLDFTGKAKWDAWNELK GTSKEDAMKAYINKVEELKK KYGI |
Tissue Specificity | Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. |
Function | Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. |
Protein Name | Acyl-Coa-Binding ProteinAcbpDiazepam-Binding InhibitorDbiEndozepineEp |
Database Links | Reactome: R-HSA-77289 |
Cellular Localisation | Endoplasmic ReticulumGolgi ApparatusGolgi Localization Is Dependent On Ligand Binding |
Alternative Antibody Names | Anti-Acyl-Coa-Binding Protein antibodyAnti-Acbp antibodyAnti-Diazepam-Binding Inhibitor antibodyAnti-Dbi antibodyAnti-Endozepine antibodyAnti-Ep antibodyAnti-DBI antibody |
Information sourced from Uniprot.org