Host: | Rabbit |
Applications: | IHC/WB |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-DBH (400-500 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Lyophilised |
Purification: | IgG purified |
Dilution Range: | IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Gene Symbol: | Dbh |
Gene ID: | 13166 |
Uniprot ID: | DOPO_MOUSE |
Immunogen Region: | 400-500 aa |
Specificity: | Specific for DBH. |
Immunogen: | A synthetic peptide from aa region 400-500 of mouse Dopamine beta-hydroxylase (DBH) conjugated to an immunogenic carrier protein was used as the antigen. |
Post Translational Modifications | Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. N-glycosylated. |
Function | Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. |
Protein Name | Dopamine Beta-HydroxylaseDopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase |
Database Links | Reactome: R-MMU-209905 |
Cellular Localisation | Soluble Dopamine Beta-Hydroxylase: Cytoplasmic VesicleSecretory Vesicle LumenCytoplasmic VesicleSecretory VesicleChromaffin Granule LumenSecretory Vesicle MembraneSingle-Pass Type Ii Membrane ProteinChromaffin Granule Membrane |
Alternative Antibody Names | Anti-Dopamine Beta-Hydroxylase antibodyAnti-Dopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase antibodyAnti-Dbh antibody |
Information sourced from Uniprot.org