| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5163RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DBH |
| Gene ID: | 1621 |
| Uniprot ID: | DOPO_HUMAN |
| Immunogen Region: | 100-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human Dopamine beta Hydroxylase (NP_000778.3). |
| Immunogen Sequence: | LVVLWTDGDTAYFADAWSDQ KGQIHLDPQQDYQLLQVQRT PEGLTLLFKRPFGTCDPKDY LIEDGTVHLVYGILEEPFRS LEAINGSGLQMGLQRVQLLK PNIPEPELPSDACTMEVQAP NIQIPSQETTYWCYIKELPK GFSRHHIIKYE |
| Post Translational Modifications | N-glycosylated. Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. |
| Function | Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. |
| Protein Name | Dopamine Beta-HydroxylaseDopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase |
| Database Links | Reactome: R-HSA-209905 |
| Cellular Localisation | Soluble Dopamine Beta-Hydroxylase: Cytoplasmic VesicleSecretory Vesicle LumenCytoplasmic VesicleSecretory VesicleChromaffin Granule LumenSecretedSecretory Vesicle MembraneSingle-Pass Type Ii Membrane ProteinChromaffin Granule Membrane |
| Alternative Antibody Names | Anti-Dopamine Beta-Hydroxylase antibodyAnti-Dopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase antibodyAnti-DBH antibody |
Information sourced from Uniprot.org