| Tissue Specificity | Expressed in neutrophils and eosinophils. Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle. |
| Post Translational Modifications | Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors. |
| Function | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytic motility by controlling cell spreading and polarization. Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death. |
| Protein Name | Death-Associated Protein Kinase 2Dap Kinase 2Dap-Kinase-Related Protein 1Drp-1 |
| Database Links | Reactome: R-HSA-418889 |
| Cellular Localisation | CytoplasmCytoplasmic VesicleAutophagosome Lumen |
| Alternative Antibody Names | Anti-Death-Associated Protein Kinase 2 antibodyAnti-Dap Kinase 2 antibodyAnti-Dap-Kinase-Related Protein 1 antibodyAnti-Drp-1 antibodyAnti-DAPK2 antibody |
Information sourced from Uniprot.org
