| Function | Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development. Antagonist of BMP and TGF-beta signaling. Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway. Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance. |
| Protein Name | Dan Domain Family Member 5Cerberus-Like Protein 2Cerl-2Cysteine Knot Superfamily 1 - Bmp Antagonist 3Gremlin-3 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617 |
| Cellular Localisation | SecretedCirculating Dand5 May Be Uptaken By Endothelial Cells And Transported To Mitochondria |
| Alternative Antibody Names | Anti-Dan Domain Family Member 5 antibodyAnti-Cerberus-Like Protein 2 antibodyAnti-Cerl-2 antibodyAnti-Cysteine Knot Superfamily 1 - Bmp Antagonist 3 antibodyAnti-Gremlin-3 antibodyAnti-DAND5 antibodyAnti-CER2 antibodyAnti-CKTSF1B3 antibodyAnti-COCO antibodyAnti-GREM3 antibodyAnti-SP1 antibody |
Information sourced from Uniprot.org
