![Anti-Cytokeratin 20 antibody [SM5160] (STJA0005160)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180210/403652/STJA0005160_1__07857.1738950657.png?c=1 "Anti-Cytokeratin 20 antibody [SM5160] (STJA0005160)")
![Anti-Cytokeratin 20 antibody [SM5160] (STJA0005160)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180210/403652/STJA0005160_1__07857.1738950657.png?c=1 "Anti-Cytokeratin 20 antibody [SM5160] (STJA0005160)")
Anti-Cytokeratin 20 antibody [SM5160] (STJA0005160)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human Cytokeratin 20
General Information
| Short Description | Mouse monoclonal anti-Cytokeratin 20 for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5160 |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC/IF (H) 1:200-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | KRT20 |
| Gene ID | 54474 |
| Uniprot ID | K1C20_HUMAN |
| Immunogen | Synthesized peptide derived from human Cytokeratin 20 |
Additional Info
| Post Translational Modifications | Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury. Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228. |
| Function | Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine. |
| Protein Name | Keratin - Type I Cytoskeletal 20Cytokeratin-20Ck-20Keratin-20K20Protein It |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 20 antibodyAnti-Cytokeratin-20 antibodyAnti-Ck-20 antibodyAnti-Keratin-20 antibodyAnti-K20 antibodyAnti-Protein It antibodyAnti-KRT20 antibody |
Information sourced from Uniprot.org