| Function | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. |
| Protein Name | Cytochrome P450 2c9(R-Limonene 6-Monooxygenase(S-Limonene 6-Monooxygenase(S-Limonene 7-MonooxygenaseCypiic9Cholesterol 25-HydroxylaseCytochrome P-450mpCytochrome P450 Mp-4Cytochrome P450 Mp-8Cytochrome P450 Pb-1S-Mephenytoin 4-Hydroxylase |
| Database Links | Reactome: R-HSA-211981Reactome: R-HSA-211999Reactome: R-HSA-2142670Reactome: R-HSA-2142816Reactome: R-HSA-9027307Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2c9 antibodyAnti-(R-Limonene 6-Monooxygenase antibodyAnti-(S-Limonene 6-Monooxygenase antibodyAnti-(S-Limonene 7-Monooxygenase antibodyAnti-Cypiic9 antibodyAnti-Cholesterol 25-Hydroxylase antibodyAnti-Cytochrome P-450mp antibodyAnti-Cytochrome P450 Mp-4 antibodyAnti-Cytochrome P450 Mp-8 antibodyAnti-Cytochrome P450 Pb-1 antibodyAnti-S-Mephenytoin 4-Hydroxylase antibodyAnti-CYP2C9 antibodyAnti-CYP2C10 antibody |
Information sourced from Uniprot.org
