| Tissue Specificity | Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart. |
| Function | Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. |
| Protein Name | Cysteinyl Leukotriene Receptor 1Cysltr1Cysteinyl Leukotriene D4 ReceptorLtd4 ReceptorG-Protein Coupled Receptor Hg55Hmtmf81 |
| Database Links | Reactome: R-HSA-391906Reactome: R-HSA-416476Reactome: R-HSA-9664535Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cysteinyl Leukotriene Receptor 1 antibodyAnti-Cysltr1 antibodyAnti-Cysteinyl Leukotriene D4 Receptor antibodyAnti-Ltd4 Receptor antibodyAnti-G-Protein Coupled Receptor Hg55 antibodyAnti-Hmtmf81 antibodyAnti-CYSLTR1 antibodyAnti-CYSLT1 antibody |
Information sourced from Uniprot.org
