| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Lanosterol 14-Alpha Demethylase (210-509) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP51A1 |
| Gene ID: |
1595 |
| Uniprot ID: |
CP51A_HUMAN |
| Immunogen Region: |
210-509 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of CYP51A1 (NP_000777.1). |
| Immunogen Sequence: |
LTASHCLHGKEIRSQLNEKV AQLYADLDGGFSHAAWLLPG WLPLPSFRRRDRAHREIKDI FYKAIQKRRQSQEKIDDILQ TLLDATYKDGRPLTDDEVAG MLIGLLLAGQHTSSTTSAWM GFFLARDKTLQKKCYLEQKT VCGENLPPLTYDQLKDLNLL DRCIKETLRLRPPIMIMMRM ARTPQTVAGYTIPPGHQVCV SPTVNQRLKDSWVERLDFNP DRYLQDNPASGEKFAYVPF |
| Tissue Specificity | Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. |
| Function | Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis. Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL. |
| Protein Name | Lanosterol 14-Alpha DemethylaseLdmCypliCytochrome P450 51a1Cyp51a1Cytochrome P450-14dmCytochrome P45014dmCytochrome P450liSterol 14-Alpha Demethylase |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-211976Reactome: R-HSA-2426168Reactome: R-HSA-9619665 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Lanosterol 14-Alpha Demethylase antibodyAnti-Ldm antibodyAnti-Cypli antibodyAnti-Cytochrome P450 51a1 antibodyAnti-Cyp51a1 antibodyAnti-Cytochrome P450-14dm antibodyAnti-Cytochrome P45014dm antibodyAnti-Cytochrome P450li antibodyAnti-Sterol 14-Alpha Demethylase antibodyAnti-CYP51A1 antibodyAnti-CYP51 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
