| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP4A11 (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP4A11 |
| Gene ID: |
1579 |
| Uniprot ID: |
CP4AB_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Cytochrome P450 4A (Cytochrome P450 4A (CYP4A11) ) (NP_000769.2). |
| Immunogen Sequence: |
MSVSVLSPSRLLGDVSGILQ AASLLILLLLLIKAVQLYLH RQWLLKALQQFPCPPSHWLF GHIQELQQDQELQRIQKWVE TFPSACPHWLWGGKVRVQLY DPDYMKVILGRSDPKSHGSY RFLAPWIGYGLLLLNGQTWF QHRRMLTPAFHYDILKPYVG LMADSVRVMLDKWEELLGQD SPLEVFQHVSLMTLDTIMKC |
| Tissue Specificity | Expressed in liver. Expressed in S2 and S3 segments of proximal tubules in cortex and outer medulla of kidney. |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid. Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver. Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency. May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening. Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer. Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids. Has little activity toward prostaglandins A1 and E1. |
| Protein Name | Cytochrome P450 4a1120-Hydroxyeicosatetraenoic Acid Synthase20-Hete SynthaseCyp4aiiCypiva11Cytochrome P-450hk-OmegaCytochrome P450hl-OmegaFatty Acid Omega-HydroxylaseLauric Acid Omega-HydroxylaseLong-Chain Fatty Acid Omega-Monooxygenase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-211935Reactome: R-HSA-211958Reactome: R-HSA-211979Reactome: R-HSA-2142691Reactome: R-HSA-2142816 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 4a11 antibodyAnti-20-Hydroxyeicosatetraenoic Acid Synthase antibodyAnti-20-Hete Synthase antibodyAnti-Cyp4aii antibodyAnti-Cypiva11 antibodyAnti-Cytochrome P-450hk-Omega antibodyAnti-Cytochrome P450hl-Omega antibodyAnti-Fatty Acid Omega-Hydroxylase antibodyAnti-Lauric Acid Omega-Hydroxylase antibodyAnti-Long-Chain Fatty Acid Omega-Monooxygenase antibodyAnti-CYP4A11 antibodyAnti-CYP4A2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
