| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP39A1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP39A1 |
| Gene ID: |
51302 |
| Uniprot ID: |
CP39A_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CYP39A1 (NP_057677.2). |
| Immunogen Sequence: |
MELISPTVIIILGCLALFLL LQRKNLRRPPCIKGWIPWIG VGFEFGKAPLEFIEKARIKY GPIFTVFAMGNRMTFVTEEE GINVFLKSKKVDFELAVQNI |
| Tissue Specificity | Liver specific. |
| Function | A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | 24-Hydroxycholesterol 7-Alpha-HydroxylaseCytochrome P450 39a1Hcyp39a1Oxysterol 7-Alpha-Hydroxylase |
| Database Links | Reactome: R-HSA-193775Reactome: R-HSA-211976 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-24-Hydroxycholesterol 7-Alpha-Hydroxylase antibodyAnti-Cytochrome P450 39a1 antibodyAnti-Hcyp39a1 antibodyAnti-Oxysterol 7-Alpha-Hydroxylase antibodyAnti-CYP39A1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
