Anti-CYP2C18 antibody (231-490) (STJ29567)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CYP2C18 (231-490) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYP2C18 |
| Gene ID | 1562 |
| Uniprot ID | CP2CI_HUMAN |
| Immunogen Region | 231-490 |
| Immunogen Sequence | NKIAENFAYIKSYVLERIKE HQESLDMNSARDFIDCFLIK MEQEKHNQQSEFTVESLIAT VTDMFGAGTETTSTTLRYGL LLLLKYPEVTAKVQEEIECV VGRNRSPCMQDRSHMPYTDA VVHEIQRYIDLLPTNLPHAV TCDVKFKNYLIPKGTTIITS LTSVLHNDKEFPNPEMFDPG HFLDKSGNFKKSDYFMPFSA GKRMCMGEGLARMELFLFLT TILQNFNLKSQVDPKDIDI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 231-490 of human CYP2C18 (NP_000763.1). |
Additional Info
| Function | A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | Cytochrome P450 2c18Cypiic18Cytochrome P450-6b/29c |
| Database Links | Reactome: R-HSA-211981 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2c18 antibodyAnti-Cypiic18 antibodyAnti-Cytochrome P450-6b/29c antibodyAnti-CYP2C18 antibody |
Information sourced from Uniprot.org