| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP1A1 (200-512) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP1A1 |
| Gene ID: |
1543 |
| Uniprot ID: |
CP1A1_HUMAN |
| Immunogen Region: |
200-512 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-512 of human CYP1A1 (NP_000490.1). |
| Immunogen Sequence: |
AICFGRRYDHNHQELLSLVN LNNNFGEVVGSGNPADFIPI LRYLPNPSLNAFKDLNEKFY SFMQKMVKEHYKTFEKGHIR DITDSLIEHCQEKQLDENAN VQLSDEKIINIVLDLFGAGF DTVTTAISWSLMYLVMNPRV QRKIQEELDTVIGRSRRPRL SDRSHLPYMEAFILETFRHS SFVPFTIPHSTTRDTSLKGF YIPKGRCVFVNQWQINHDQK LWVNPSEFLPERFLTPDGA |
| Tissue Specificity | Lung, lymphocytes and placenta. |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). |
| Protein Name | Cytochrome P450 1a1Cypia1Cytochrome P450 Form 6Cytochrome P450-CCytochrome P450-P1Hydroperoxy Icosatetraenoate Dehydratase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-211981Reactome: R-HSA-2142670Reactome: R-HSA-2142816Reactome: R-HSA-9018681 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMitochondrion Inner MembraneMicrosome MembraneCytoplasm |
| Alternative Antibody Names | Anti-Cytochrome P450 1a1 antibodyAnti-Cypia1 antibodyAnti-Cytochrome P450 Form 6 antibodyAnti-Cytochrome P450-C antibodyAnti-Cytochrome P450-P1 antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-CYP1A1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
