Host: | Mouse |
Applications: | FC/IF |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Mouse monoclonal antibody anti-Cytochrome C is suitable for use in Flow Cytometry and Immunofluorescence research applications. |
Clonality : | Monoclonal |
Clone ID : | 1D3 |
Conjugation: | PE |
Isotype: | IgG2ak |
Formulation: | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. |
Purification: | Purified |
Concentration: | 0.5 mg/mL |
Storage Instruction: | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Function | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. |
Protein Name | Cytochrome C |
Database Links | Reactome: R-HSA-111457Reactome: R-HSA-111458Reactome: R-HSA-111459Reactome: R-HSA-111463Reactome: R-HSA-111464Reactome: R-HSA-2151201Reactome: R-HSA-3299685Reactome: R-HSA-5620971Reactome: R-HSA-5628897Reactome: R-HSA-611105Reactome: R-HSA-9627069Reactome: R-HSA-9707564 |
Cellular Localisation | Mitochondrion Intermembrane SpaceLoosely Associated With The Inner Membrane |
Alternative Antibody Names | Anti-Cytochrome C antibodyAnti-CYCS antibodyAnti-CYC antibody |
Information sourced from Uniprot.org