| Host: | Rabbit |
| Applications: | WB/IHC-F/IHC-P/ICC/IF |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-Cyclin E2 for use in WB, IHC-F, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R02-1C0 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: | Affinity Purified |
| Concentration: | 0.3 mg/mL |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | CCNE2 |
| Gene ID: | 9134 |
| Uniprot ID: | CCNE2_HUMAN |
| Immunogen: | A synthetic peptide of human Cyclin E2 |
| Tissue Specificity | highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. : low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. |
| Post Translational Modifications | Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway. Lactylated at Lys-348. Delactylated by SIRT3. |
| Function | Essential for the control of the cell cycle at the late G1 and early S phase. |
| Protein Name | G1/S-Specific Cyclin-E2 |
| Database Links | Reactome: R-HSA-1538133Reactome: R-HSA-187577Reactome: R-HSA-2559586Reactome: R-HSA-390471Reactome: R-HSA-6804116Reactome: R-HSA-69017Reactome: R-HSA-69200Reactome: R-HSA-69202Reactome: R-HSA-69231Reactome: R-HSA-69563Reactome: R-HSA-9661069 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-G1/S-Specific Cyclin-E2 antibodyAnti-CCNE2 antibody |
Information sourced from Uniprot.org