| Host: | Rabbit |
| Applications: | WB/IHC-F/IHC-P/ICC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-Cyclin A2 for use in WB, IHC-F, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R06-5H1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: | Affinity Purified |
| Concentration: | 0.3 mg/mL |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | Ccna2 |
| Gene ID: | 12428 |
| Uniprot ID: | CCNA2_MOUSE |
| Immunogen: | Recombinant protein of mouse Cyclin A2 |
| Tissue Specificity | Ubiquitous. In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells. |
| Post Translational Modifications | Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation. |
| Function | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. |
| Protein Name | Cyclin-A2Cyclin-A |
| Database Links | Reactome: R-MMU-1538133Reactome: -MMU-171319Reactome: -MMU-174184Reactome: -MMU-176408Reactome: -MMU-187577Reactome: -MMU-2559582Reactome: -MMU-2559586Reactome: -MMU-5689880Reactome: -MMU-5693607Reactome: -MMU-6804116Reactome: -MMU-6804756Reactome: -MMU-6804757Reactome: -MMU-68911Reactome: -MMU-68949Reactome: -MMU-69017Reactome: -MMU-69273Reactome: -MMU-69563Reactome: -MMU-69656 |
| Cellular Localisation | NucleusCytoplasmExclusively Nuclear During InterphaseDetected In The Nucleus And The Cytoplasm At ProphaseCytoplasmic When Associated With Scaper |
| Alternative Antibody Names | Anti-Cyclin-A2 antibodyAnti-Cyclin-A antibodyAnti-Ccna2 antibodyAnti-Ccna antibodyAnti-Cyca antibodyAnti-Cyca2 antibody |
Information sourced from Uniprot.org
![Anti-Cyclin A2 antibody [SM4920] (STJA0004920)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/179995/403154/STJA0004920_1__06696.1738950261.png?c=1 "Anti-Cyclin A2 antibody [SM4920] (STJA0004920)")