| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYBRD1 |
| Gene ID: |
79901 |
| Uniprot ID: |
CYBR1_HUMAN |
| Immunogen Region: |
215-286 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 215-286 of human CYBRD1 (NP_079119.3). |
| Immunogen Sequence: |
IFWIVTRPQWKRPKEPNSTI LHPNGGTEQGARGSMPAYSG NNMDKSDSELNSEVAARKRN LALDEAGQRSTM |
| Tissue Specificity | Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium. |
| Function | Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase. |
| Protein Name | Plasma Membrane Ascorbate-Dependent Reductase Cybrd1Cytochrome B Reductase 1Duodenal Cytochrome BFerric-Chelate Reductase 3 |
| Database Links | Reactome: R-HSA-917937 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneLocalized At The Brush Border Of Duodenal Cells |
| Alternative Antibody Names | Anti-Plasma Membrane Ascorbate-Dependent Reductase Cybrd1 antibodyAnti-Cytochrome B Reductase 1 antibodyAnti-Duodenal Cytochrome B antibodyAnti-Ferric-Chelate Reductase 3 antibodyAnti-CYBRD1 antibodyAnti-DCYTB antibodyAnti-FRRS3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
