Immunofluorescence analysis of Jurkat cells using CXCR2 Rabbit polyclonal antibody (STJ11100902) at dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-CXCR2 antibody (260-359) (STJ11100902)

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STJ11100902
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CXCR2
Gene ID: 3579
Uniprot ID: CXCR2_HUMAN
Immunogen Region: 260-359
Specificity: A synthetic peptide corresponding to a sequence within amino acids 260-359 of human CXCR2 (NP_001548.1).
Immunogen Sequence: FLLCWLPYNLVLLADTLMRT QVIQETCERRNHIDRALDAT EILGILHSCLNPLIYAFIGQ KFRHGLLKILAIHGLISKDS LPKDSRPSFVGSSSGHTSTT
Post Translational Modifications Phosphorylated upon ligand binding.which is required for desensitization. (Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis.
Function Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Protein Name C-X-C Chemokine Receptor Type 2
Cxc-R2
Cxcr-2
Cdw128b
Gro/Mgsa Receptor
High Affinity Interleukin-8 Receptor B
Il-8r B
Il-8 Receptor Type 2
Cd Antigen Cd182
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-C-X-C Chemokine Receptor Type 2 antibody
Anti-Cxc-R2 antibody
Anti-Cxcr-2 antibody
Anti-Cdw128b antibody
Anti-Gro/Mgsa Receptor antibody
Anti-High Affinity Interleukin-8 Receptor B antibody
Anti-Il-8r B antibody
Anti-Il-8 Receptor Type 2 antibody
Anti-Cd Antigen Cd182 antibody
Anti-CXCR2 antibody
Anti-IL8RB antibody

Information sourced from Uniprot.org

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