| Post Translational Modifications | Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans. |
| Function | Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development.required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells. |
| Protein Name | Stromal Cell-Derived Factor 1Sdf-1Hsdf-1C-X-C Motif Chemokine 12Intercrine Reduced In HepatomasIrhHirhPre-B Cell Growth-Stimulating FactorPbsf Cleaved Into - Sdf-1-Beta(3-72 - Sdf-1-Alpha(3-67 |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-376176Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-9018519 |
| Cellular Localisation | Secreted |
| Alternative Nanobody Names | Anti-Stromal Cell-Derived Factor 1 nanobodyAnti-Sdf-1 nanobodyAnti-Hsdf-1 nanobodyAnti-C-X-C Motif Chemokine 12 nanobodyAnti-Intercrine Reduced In Hepatomas nanobodyAnti-Irh nanobodyAnti-Hirh nanobodyAnti-Pre-B Cell Growth-Stimulating Factor nanobodyAnti-Pbsf Cleaved Into - Sdf-1-Beta(3-72 - Sdf-1-Alpha(3-67 nanobodyAnti-CXCL12 nanobodyAnti-SDF1 nanobodyAnti-SDF1A nanobodyAnti-SDF1B nanobody |
Information sourced from Uniprot.org
![Anti-CXCL12/SDF-1 nanobody [SAA1273] (STJN000229)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200842/413024/STJN000229-SDS-PAGE-1__93914.1749232540.jpg?c=1 "Anti-CXCL12/SDF-1 nanobody [SAA1273] (STJN000229)")
![Anti-CXCL12/SDF-1 nanobody [SAA1273] (STJN000229)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200842/413024/STJN000229-SDS-PAGE-1__93914.1749232540.jpg?c=1 "Anti-CXCL12/SDF-1 nanobody [SAA1273] (STJN000229)")
