Anti-CXADR antibody [SAA0357] (STJA0019307)

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STJA0019307
€473.13 - €2,040.63
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Host: Mouse
Applications: Blocking/FC/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Coxsackievirus And Adenovirus Receptor is suitable for use in Universaling, Flow Cytometry and Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : SAA0357
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: CXADR
Gene ID: 1525
Uniprot ID: CXAR_HUMAN
Post Translational Modifications N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260.required for proper localization to the plasma membrane.
Function Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
Protein Name Coxsackievirus And Adenovirus Receptor
Car
Hcar
Cvb3-Binding Protein
Coxsackievirus B-Adenovirus Receptor
Hcvadr
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-202733
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Basolateral Cell Membrane
Cell Junction
Tight Junction
Adherens Junction
In Epithelial Cells Localizes To The Apical Junction Complex Composed Of Tight And Adherens Junctions
In Airway Epithelial Cells Localized To Basolateral Membrane But Not To Apical Surface
Isoform 3: Secreted
Isoform 4: Secreted
Isoform 5: Secreted
Alternative Antibody Names Anti-Coxsackievirus And Adenovirus Receptor antibody
Anti-Car antibody
Anti-Hcar antibody
Anti-Cvb3-Binding Protein antibody
Anti-Coxsackievirus B-Adenovirus Receptor antibody
Anti-Hcvadr antibody
Anti-CXADR antibody
Anti-CAR antibody

Information sourced from Uniprot.org