| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CWC22 |
| Gene ID: | 57703 |
| Uniprot ID: | CWC22_HUMAN |
| Immunogen Region: | 639-908 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 639-908 of human CWC22 (NP_065994.1). |
| Immunogen Sequence: | LTDELREHLKNTPKVIVAQK PDVEQNKSSPSSSSSASSSS ESDSSDSDSDSSDSSSESSS EESDSSSISSHSSASANDVR KKGHGKTRSKEVDKLIRNQQ TNDRKQKERRQEHGHQETRT ERERRSEKHRDQNSSGSNWR DPITKYTSDKDVPSERNNYS RVANDRDQEMHIDLENKHGD PKKKRGERRNSFSENEKHTH RIKDSENFRRKDRSKSKEMN RKHSGSRSDEDRYQNGAER |
| Function | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. |
| Protein Name | Pre-Mrna-Splicing Factor Cwc22 HomologNucampholin HomologFsapb |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleConcentrates Around SpecklesWhich Are Sites Of Pre-Mrna Synthesis And ProcessingWhere It Colocalizes With Ejc Core Proteins |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Cwc22 Homolog antibodyAnti-Nucampholin Homolog antibodyAnti-Fsapb antibodyAnti-CWC22 antibodyAnti-KIAA1604 antibodyAnti-NCM antibody |
Information sourced from Uniprot.org
