| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CTSK |
| Gene ID: | 1513 |
| Uniprot ID: | CATK_HUMAN |
| Immunogen Region: | 115-329 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-329 of human CTSK (NP_000387.1). |
| Immunogen Sequence: | APDSVDYRKKGYVTPVKNQG QCGSCWAFSSVGALEGQLKK KTGKLLNLSPQNLVDCVSEN DGCGGGYMTNAFQYVQKNRG IDSEDAYPYVGQEESCMYNP TGKAAKCRGYREIPEGNEKA LKRAVARVGPVSVAIDASLT SFQFYSKGVYYDESCNSDNL NHAVLAVGYGIQKGNKHWII KNSWGENWGNKGYILMARNK NNACGIANLASFPKM |
| Tissue Specificity | Predominantly expressed in osteoclasts (bones). Expressed in thyroid epithelial cells. |
| Function | Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. |
| Protein Name | Cathepsin KCathepsin OCathepsin O2Cathepsin X |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228Reactome: R-HSA-1592389Reactome: R-HSA-1679131Reactome: R-HSA-2132295Reactome: R-HSA-8939242 |
| Cellular Localisation | LysosomeSecretedApical Cell MembranePeripheral Membrane ProteinExtracellular SideLocalizes To The Lumen Of Thyroid Follicles And To The Apical Membrane Of Thyroid Epithelial Cells |
| Alternative Antibody Names | Anti-Cathepsin K antibodyAnti-Cathepsin O antibodyAnti-Cathepsin O2 antibodyAnti-Cathepsin X antibodyAnti-CTSK antibodyAnti-CTSO antibodyAnti-CTSO2 antibody |
Information sourced from Uniprot.org