Anti-CTSB antibody (8-339) [S4983RM] (STJ11104983)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Cathepsin B (8-339) antibody for use in WB, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4983RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CTSB |
| Gene ID | 1508 |
| Uniprot ID | CATB_HUMAN |
| Immunogen Region | 8-339 |
| Immunogen Sequence | CCLLVLANARSRPSFHPLSD ELVNYVNKRNTTWQAGHNFY NVDMSYLKRLCGTFLGGPKP PQRVMFTEDLKLPASFDARE QWPQCPTIKEIRDQGSCGSC WAFGAVEAISDRICIHTNAH VSVEVSAEDLLTCCGSMCGD GCNGGYPAEAWNFWTRKGLV SGGLYESHVGCRPYSIPPCE HHVNGSRPPCTGEGDTPKCS KICEPGYSPTYKQDKHYGYN SYSVSNSEKDIMAEIYKNG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 8-339 of human Cathepsin B. |
Additional Info
| Tissue Specificity | Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum. |
| Function | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis. |
| Protein Name | Cathepsin BApp SecretaseAppsCathepsin B1 Cleaved Into - Cathepsin B Light Chain - Cathepsin B Heavy Chain |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1679131Reactome: R-HSA-2022090Reactome: R-HSA-2132295Reactome: R-HSA-6798695 |
| Cellular Localisation | LysosomeMelanosomeSecretedExtracellular SpaceApical Cell MembranePeripheral Membrane ProteinExtracellular SideIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvLocalizes To The Lumen Of Thyroid Follicles And To The Apical Membrane Of Thyroid Epithelial Cells |
| Alternative Antibody Names | Anti-Cathepsin B antibodyAnti-App Secretase antibodyAnti-Apps antibodyAnti-Cathepsin B1 Cleaved Into - Cathepsin B Light Chain - Cathepsin B Heavy Chain antibodyAnti-CTSB antibodyAnti-CPSB antibody |
Information sourced from Uniprot.org