| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CTPS1 |
| Gene ID: | 1503 |
| Uniprot ID: | PYRG1_HUMAN |
| Immunogen Region: | 402-591 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 402-591 of human CTPS1 (NP_001896.2). |
| Immunogen Sequence: | MQLAVVEFSRNVLGWQDANS TEFDPTTSHPVVVDMPEHNP GQMGGTMRLGKRRTLFQTKN SVMRKLYGDADYLEERHRHR FEVNPVWKKCLEEQGLKFVG QDVEGERMEIVELEDHPFFV GVQYHPEFLSRPIKPSPPYF GLLLASVGRLSHYLQKGCRL SPRDTYSDRSGSSSPDSEIT ELKFPSINHD |
| Tissue Specificity | Widely expressed. |
| Function | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. |
| Protein Name | Ctp Synthase 1Ctp Synthetase 1Utp--Ammonia Ligase 1 |
| Database Links | Reactome: R-HSA-499943 |
| Cellular Localisation | CytoplasmCytosolMainly Cytosolic But When Active Detected In Long Filamentous StructuresCo-Localizes With Tnk2 In The Cytosolic Filaments |
| Alternative Antibody Names | Anti-Ctp Synthase 1 antibodyAnti-Ctp Synthetase 1 antibodyAnti-Utp--Ammonia Ligase 1 antibodyAnti-CTPS1 antibodyAnti-CTPS antibody |
Information sourced from Uniprot.org