| Host: | Mouse |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-cTnT (139-152) is suitable for use in ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 3711 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Purification: | Greater than 95% purity |
| Concentration: | 5.0 mg/ml (+/-10 %) |
| Storage Instruction: | Unspecified, storage at 2–8°C. Temperature analysis:-70 °C, 21 days Not Determined (N/D)-20 °C, 14 days OK +4 °C, 14 days OK +35 °C, 14 days OK +45 °C, 7 days OK. Shelf life stability testing at 2–8 °C in the product buffer. |
| Association Rate Constant: | 2.1 x 106 1/Ms |
| Determination Method: | SPR analysis (ProteOn XPR36) |
| Immunoreactivity: | 80–120 % compared to the reference sample in an FIA test |
| Gene Symbol: | TNNT2 |
| Gene ID: | 7139 |
| Uniprot ID: | TNNT2_HUMAN |
| Immunogen Region: | 139-152 |
| Immunogen: | Human cardiac troponin T (cTnT) |
| Tissue Specificity | Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. |
| Post Translational Modifications | Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity. |
| Function | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Protein Name | Troponin T - Cardiac MuscleTntcCardiac Muscle Troponin TCtnt |
| Database Links | Reactome: R-HSA-390522 |
| Alternative Antibody Names | Anti-Troponin T - Cardiac Muscle antibodyAnti-Tntc antibodyAnti-Cardiac Muscle Troponin T antibodyAnti-Ctnt antibodyAnti-TNNT2 antibody |
Information sourced from Uniprot.org