Anti-CTNNA1 antibody (N-Term) (STJA0005299)

SKU:
STJA0005299-100

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Host: Rabbit
Applications: WB
Reactivity: Chicken/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Alpha 1-Catenin (N-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CTNNA1
Gene ID: 1495
Uniprot ID: CTNA1_HUMAN
Immunogen Region: N-Term
Specificity: The antibody detects a 102 kDa* protein corresponding to the molecular mass of Alpha 1-Catenin on SDS-PAGE immunoblots of rat PC12 and mouse SYF cells.
Immunogen: Alpha 1-Catenin synthetic peptide (coupled to KLH) corresponding to amino acid residues from the N-terminal region of human Alpha 1-Catenin. This peptide sequence is highly conserved in rat and mouse Alpha 1-Catenin, and has some homology to Alpha 2-
Tissue Specificity Isoform 1: Ubiquitously expressed in normal tissues. Isoform 3: Abundantly expressed in brain and cerebellum, also expressed in the placenta, liver, lung, colon, heart, pancreas, stomach and thymus.
Post Translational Modifications Sumoylated. Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.
Function Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. May play a crucial role in cell differentiation.
Protein Name Catenin Alpha-1
Alpha E-Catenin
Cadherin-Associated Protein
Renal Carcinoma Antigen Ny-Ren-13
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-5218920
Reactome: R-HSA-525793
Reactome: R-HSA-5626467
Reactome: R-HSA-9762292
Reactome: R-HSA-9764302
Reactome: R-HSA-9833576
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Junction
Adherens Junction
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Nucleus
Found At Cell-Cell Boundaries And Probably At Cell-Matrix Boundaries
Isoform 3: Cell Membrane
Alternative Antibody Names Anti-Catenin Alpha-1 antibody
Anti-Alpha E-Catenin antibody
Anti-Cadherin-Associated Protein antibody
Anti-Renal Carcinoma Antigen Ny-Ren-13 antibody
Anti-CTNNA1 antibody

Information sourced from Uniprot.org

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