| Function | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. |
| Protein Name | Carboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 2Nuclear Lim Interactor-Interacting Factor 2Nli-Interacting Factor 2Protein Os-4Small C-Terminal Domain Phosphatase 2Small Ctd Phosphatase 2Scp2 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Carboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 2 antibodyAnti-Nuclear Lim Interactor-Interacting Factor 2 antibodyAnti-Nli-Interacting Factor 2 antibodyAnti-Protein Os-4 antibodyAnti-Small C-Terminal Domain Phosphatase 2 antibodyAnti-Small Ctd Phosphatase 2 antibodyAnti-Scp2 antibodyAnti-CTDSP2 antibodyAnti-NIF2 antibodyAnti-OS4 antibodyAnti-SCP2 antibody |
Information sourced from Uniprot.org
