| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-RNA polymerase II subunit A C-terminal domain phosphatase (73-123 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CTDP1 |
| Gene ID: | 9150 |
| Uniprot ID: | CTDP1_HUMAN |
| Immunogen Region: | 73-123 aa |
| Specificity: | This antibody detects endogenous levels of CTDP1 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human CTDP1 at the amino acid range 73-123 |
| Post Translational Modifications | Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1. |
| Function | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. |
| Protein Name | Rna Polymerase Ii Subunit A C-Terminal Domain PhosphataseTfiif-Associating Ctd Phosphatase |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167200Reactome: R-HSA-167238Reactome: R-HSA-167242Reactome: R-HSA-167243Reactome: R-HSA-167246Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-75955 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleMidbodyFound At Centrosomes In PrometaphaseAt Spindle And Spindle Poles In Metaphase And At Spindle Midzone And Midbody In Anaphase And Telophase-G1 Respectively |
| Alternative Antibody Names | Anti-Rna Polymerase Ii Subunit A C-Terminal Domain Phosphatase antibodyAnti-Tfiif-Associating Ctd Phosphatase antibodyAnti-CTDP1 antibodyAnti-FCP1 antibody |
Information sourced from Uniprot.org
