| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CST6 |
| Gene ID: | 1474 |
| Uniprot ID: | CYTM_HUMAN |
| Immunogen Region: | 29-149 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-149 of human CST6 (NP_001314.1). |
| Immunogen Sequence: | RPQERMVGELRDLSPDDPQV QKAAQAAVASYNMGSNSIYY FRDTHIIKAQSQLVAGIKYF LTMEMGSTDCRKTRVTGDHV DLTTCPLAAGAQQEKLRCDF EVLVVPWQNSSQLLKHNCVQ M |
| Tissue Specificity | Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity. |
| Post Translational Modifications | Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor. |
| Function | High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain. Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance. |
| Protein Name | Cystatin-MCystatin-6Cystatin-E |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Cystatin-M antibodyAnti-Cystatin-6 antibodyAnti-Cystatin-E antibodyAnti-CST6 antibody |
Information sourced from Uniprot.org