| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CSNK2B |
| Gene ID: | 1460 |
| Uniprot ID: | CSK2B_HUMAN |
| Immunogen Region: | 101-215 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 101-215 of human Casein Kinase 2 beta (CSNK2B) (CSNK2B) (P67870). |
| Immunogen Sequence: | YQQGDFGYCPRVYCENQPML PIGLSDIPGEAMVKLYCPKC MDVYTPKSSRHHHTDGAYFG TGFPHMLFMVHPEYRPKRPA NQFVPRLYGFKIHPMAYQLQ LQAASNFKSPVKTIR |
| Post Translational Modifications | Phosphorylated by alpha subunit. |
| Function | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling. (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML. Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition. |
| Protein Name | Casein Kinase Ii Subunit Beta Ck Ii Beta Phosvitin Protein G5a |
| Database Links | Reactome: R-HSA-1483191 Reactome: R-HSA-201688 Reactome: R-HSA-2514853 Reactome: R-HSA-445144 Reactome: R-HSA-6798695 Reactome: R-HSA-6804756 Reactome: R-HSA-6814122 Reactome: R-HSA-8934903 Reactome: R-HSA-8939243 Reactome: R-HSA-8948751 Reactome: R-HSA-9755511 Reactome: R-HSA-9828806 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Casein Kinase Ii Subunit Beta antibody Anti-Ck Ii Beta antibody Anti-Phosvitin antibody Anti-Protein G5a antibody Anti-CSNK2B antibody Anti-CK2N antibody Anti-G5A antibody |
Information sourced from Uniprot.org