| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:6000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CSNK1A1 |
| Gene ID: | 1452 |
| Uniprot ID: | KC1A_HUMAN |
| Immunogen Region: | 238-337 |
| Immunogen Sequence: | EKKMSTPVEVLCKGFPAEFA MYLNYCRGLRFEEAPDYMYL RQLFRILFRTLNHQYDYTFD WTMLKQKAAQQAASSSGQGQ QAQTPTGKQTDKTKSNMKGF |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 238-337 of human Casein Kinase 1 alpha (CSNK1A1) (P48729). |
| Post Translational Modifications | Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation. |
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor. Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3. |
| Protein Name | Casein Kinase I Isoform AlphaCki-AlphaCk1 |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5635838Reactome: R-HSA-9694631 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeChromosomeCentromereKinetochoreNucleus SpeckleCilium Basal BodySpindleLocalizes To The Centrosome In Interphase CellsAnd To Kinetochore Fibers During MitosisAlso Recruited To The Keratin Cytoskeleton |
| Alternative Antibody Names | Anti-Casein Kinase I Isoform Alpha antibodyAnti-Cki-Alpha antibodyAnti-Ck1 antibodyAnti-CSNK1A1 antibody |
Information sourced from Uniprot.org
