Anti-Csk-binding protein antibody (STJ16101301)

SKU:
STJ16101301-01

£521.50
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Host: Rabbit
Applications: IP/WB/IHC-P
Reactivity: Mouse/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Csk-binding protein is suitable for use in Immunoprecipitation, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purification: Affinity purified
Concentration: 1 mg/mL
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: PAG1
Gene ID: 55824
Uniprot ID: PHAG1_HUMAN
Immunogen: Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG).
Tissue Specificity Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
Post Translational Modifications Palmitoylated. Phosphorylated by FYN on Tyr-317 in resting T-cells.which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation.which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.
Function Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Protein Name Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1
Csk-Binding Protein
Transmembrane Adapter Protein Pag
Transmembrane Phosphoprotein Cbp
Database Links Reactome: R-HSA-180292
Reactome: R-HSA-202427
Cellular Localisation Cell Membrane
Single-Pass Type Iii Membrane Protein
Present In Lipid Rafts
Alternative Antibody Names Anti-Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1 antibody
Anti-Csk-Binding Protein antibody
Anti-Transmembrane Adapter Protein Pag antibody
Anti-Transmembrane Phosphoprotein Cbp antibody
Anti-PAG1 antibody
Anti-CBP antibody
Anti-PAG antibody

Information sourced from Uniprot.org

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