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Primary Antibodies
Polyclonal Antibodies
Anti-CSK antibody (C-Term) (STJ70044)

STJ70044 (0. 1µg/ml) staining of Jurkat lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
STJ70044 (4µg/ml) staining of paraffin embedded Human Colon. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. This data is from a previous batch, not on sale.

Anti-CSK antibody (C-Term) (STJ70044)

SKU:

STJ70044-100

£303.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	Goat
Applications:	Pep-ELISA/WB
Reactivity:	Human/Mouse/Rat/Dog/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-CSK (C-Term) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.1-0.3µg/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	CSK
Gene ID:	1445
Uniprot ID:	CSK_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_004374.1
Specificity:	Reported variants represent identical protein: NP_004374.1; NP_001120662.1.
Immunogen Sequence:	EQLEHIKTHELHL

Post Translational Modifications	Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
Function	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Protein Name	Tyrosine-Protein Kinase Csk C-Src Kinase Protein-Tyrosine Kinase Cyl
Database Links	Reactome: R-HSA-180292 Reactome: R-HSA-202427 Reactome: R-HSA-354192 Reactome: R-HSA-389948 Reactome: R-HSA-5674135 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9013407 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9706369
Cellular Localisation	Cytoplasm Cell Membrane Mainly Cytoplasmic Also Present In Lipid Rafts
Alternative Antibody Names	Anti-Tyrosine-Protein Kinase Csk antibody Anti-C-Src Kinase antibody Anti-Protein-Tyrosine Kinase Cyl antibody Anti-CSK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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