• Anti-CRK antibody [3G11E8] (STJ97969)
  • Flow cytometric analysis of Hela cells using Crk II monoclonal antibody (blue) and negative control (red).
  • Immunohistochemistry analysis of paraffin-embedded intima cancer tissues with DAB staining using Crk II monoclonal antibody.
  • Immunofluorescence analysis of 3T3-L1 cells using Crk II monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • Western blot analysis using Crk II monoclonal antibody against HEK293 (1) and CRK-hIgGFc transfected HEK293 (2) cell lysate.

Anti-CRK antibody [3G11E8] (STJ97969)

SKU:
STJ97969

£139.00 - £336.00
Current Stock:
Host: Mouse
Applications: WB/IHC/IF/FC/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Adapter molecule crk is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA research applications.
Clonality: Monoclonal
Clone ID: 3G11E8
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
FC 1:200-1:400
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRK
Gene ID: 1398
Uniprot ID: CRK_HUMAN
Specificity: Crk II Monoclonal Antibody detects endogenous levels of Crk II protein.
Immunogen: Purified recombinant fragment of human Crk II expressed in E. Coli.
Function Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Protein Name Adapter Molecule Crk
Proto-Oncogene C-Crk
P38
Database Links Reactome: R-HSA-170984
Reactome: R-HSA-186763
Reactome: R-HSA-2029482
Reactome: R-HSA-372708
Reactome: R-HSA-4420097
Reactome: R-HSA-8849471
Reactome: R-HSA-8875555
Reactome: R-HSA-8875656
Reactome: R-HSA-912631
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Cell Membrane
Translocated To The Plasma Membrane Upon Cell Adhesion
Alternative Antibody Names Anti-Adapter Molecule Crk antibody
Anti-Proto-Oncogene C-Crk antibody
Anti-P38 antibody
Anti-CRK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance