Anti-CRK antibody (187-236 aa) (STJ92477)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CrkII at the amino acid range 187-236
General Information
| Short Description | Rabbit polyclonal anti-Adapter molecule crk (187-236 aa) for use in WB, IHC, IF and ELISA in Human, Mouse, Rat and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRK |
| Gene ID | 1398 |
| Uniprot ID | CRK_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CrkII at the amino acid range 187-236 |
| Immunogen Region | 187-236 aa |
| Specificity | Crk II Polyclonal Antibody detects endogenous levels of Crk II protein. |
Additional Info
| Function | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
| Protein Name | Adapter Molecule CrkProto-Oncogene C-CrkP38 |
| Database Links | Reactome: R-HSA-170984Reactome: R-HSA-186763Reactome: R-HSA-2029482Reactome: R-HSA-372708Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-8875555Reactome: R-HSA-8875656Reactome: R-HSA-912631Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCell MembraneTranslocated To The Plasma Membrane Upon Cell Adhesion |
| Alternative Antibody Names | Anti-Adapter Molecule Crk antibodyAnti-Proto-Oncogene C-Crk antibodyAnti-P38 antibodyAnti-CRK antibody |
Information sourced from Uniprot.org