• STJ70609 staining (1µg/ml) of Human Heart lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by chemiluminescence.

Anti-CREM antibody (C-Term) (STJ70609)

SKU:
STJ70609-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-CREM (C-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CREM
Gene ID: 1390
Uniprot ID: CREM_HUMAN
Immunogen Region: C-Term
Accession Number: NP_853549.1; NP_874387.1; NP_874388.1; NP_874393.1; NP_874394.1; NP_877570.1; NP_877571.1; NP_877572.1; NP_877573.1; NP_878270.1; NP_898883.1
Specificity: This antibody is expected to recognise the following protein isoforms of human CREM protein: a (NP_853549.1) ; e (NP_874387.1) ; f (NP_874388.1) ; k (NP_874393.1) ; l (NP_874394.1) ; m (NP_877570.1) ; n (NP_877571.1) ; o (NP_877572.1) ; p (NP_877573.
Immunogen Sequence: LETLKDICSPKTDY
Post Translational Modifications Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro.
Function Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Protein Name Camp-Responsive Element Modulator
Inducible Camp Early Repressor
Icer
Database Links Reactome: R-HSA-400253 Q03060-6
Cellular Localisation Nucleus
Isoform 6: Cytoplasm
Alternative Antibody Names Anti-Camp-Responsive Element Modulator antibody
Anti-Inducible Camp Early Repressor antibody
Anti-Icer antibody
Anti-CREM antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance